Bradykinin catabolic process

Across TCGA patient cohorts, RNA activity of the Bradykinin catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MME, MME_S6, and ACE, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bradykinin catabolic process activity versus MME in COAD (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MME →	+0.816	+0.063	<.001	<.001	3	7
LSCC	MME_S6 →	+0.793	+0.067	<.001	<.001	3	7
PDAC	ACE →	+0.434	+0.054	<.001	<.001	3	6
LSCC	AFAP1L2 →	+0.510	+0.076	<.001	<.001	3	5
GBM	ENPP2 →	+0.538	+0.045	<.001	.001	3	5
BRCA	CHEK1 →	-0.369	-0.042	.005	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010815 vs MME — COAD

Explore this scatter interactively →