Bradykinin catabolic process

Across TCGA patient cohorts, RNA activity of the Bradykinin catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MME, LYVE1, and MMP19, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bradykinin catabolic process activity versus MME in LSCC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MME →	+1.209	+0.200	.003	<.001	2	7
HNSC	LYVE1 →	+1.199	+0.129	<.001	.001	3	6
GBM	MMP19 →	+1.050	+0.138	.001	<.001	3	5
GBM	CD93 →	+0.687	+0.129	.001	<.001	3	5
LSCC	BEST1 →	+0.221	+0.109	.005	.006	3	5
LSCC	CLEC14A →	+0.349	+0.112	.003	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010815 vs MME — LSCC

Explore this scatter interactively →