Bradykinin catabolic process

Across TCGA cell cohorts, RNA activity of the Bradykinin catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TARBP1, RNF157, and TRIM11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bradykinin catabolic process activity versus TARBP1 in LIVER (Pearson r = -0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TARBP1 →	-1.012	-1.032	<.001	.004	3	6
KIDNEY	RNF157 →	-2.163	-1.374	<.001	.002	3	5
STOMACH	TRIM11 →	-0.772	-1.057	<.001	<.001	3	5
BLOOD_Leukemia	MT-ATP8 →	-0.705	-0.653	.008	.005	3	5
OESOPHAGUS	CLASRP →	-0.738	-1.187	.001	.002	3	4
PANCREAS	C22orf46 →	-0.892	-1.459	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010815 vs TARBP1 — LIVER

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