Negative regulation of cell-substrate adhesion

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell-substrate adhesion pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCL, VCL_S795, and CLEC3B, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell-substrate adhesion activity versus VCL in CCRCC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	VCL →	+0.446	+0.055	<.001	<.001	3	10
BRCA	VCL_S795 →	+0.722	+0.051	<.001	<.001	3	10
CCRCC	CLEC3B →	+0.633	+0.044	<.001	<.001	3	10
CCRCC	COL3A1 →	+0.747	+0.045	.007	<.001	3	10
GBM	FBLN2 →	+0.810	+0.054	<.001	.001	3	10
OV	HSPG2 →	+0.486	+0.050	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010812 vs VCL — CCRCC

Explore this scatter interactively →