Negative regulation of cell-substrate adhesion

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell-substrate adhesion pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NGF, SAMD4A, and GPIHBP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell-substrate adhesion activity versus NGF in OV (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NGF →	+0.946	+0.490	<.001	.008	3	4
UCEC	SAMD4A →	+0.792	+0.718	.002	.002	3	4
GBM	GPIHBP1 →	+0.904	+0.153	.003	.003	3	4
COAD	TGFB3 →	+0.793	+0.444	.003	.005	3	4
BRCA	LINC02019 →	+0.356	+0.125	.003	.002	3	4
UCEC	LINC00499 →	+0.330	+0.491	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010812 vs NGF — OV

Explore this scatter interactively →