Negative regulation of cell-substrate adhesion

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell-substrate adhesion pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FXYD5, ATP8A1, and PDP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell-substrate adhesion activity versus FXYD5 in OVARY (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FXYD5 →	+2.923	+0.250	.006	.004	3	6
OVARY	ATP8A1 →	-1.165	-0.198	.004	.004	3	5
OVARY	PDP1 →	+1.222	+0.246	.009	<.001	3	5
OVARY	GLDC →	-2.716	-0.214	.002	.002	3	5
LUNG_NSCLC_LUSC	PDLIM7 →	+2.687	+0.653	.003	.001	3	5
SKIN	SLC31A1 →	-1.036	-0.274	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010812 vs FXYD5 — OVARY

Explore this scatter interactively →