Regulation of cell-substrate adhesion

Across TCGA cell cohorts, RNA activity of the Regulation of cell-substrate adhesion pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRIM1, RPP25, and ZMYM2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CRIM1 grouped by Regulation of cell-substrate adhesion-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CRIM1 →	-0.266	-0.866	<.001	.001	3	4
SOFT_TISSUE	RPP25 →	-0.236	-0.151	.006	.005	3	4
OESOPHAGUS	ZMYM2 →	+0.185	+0.139	<.001	<.001	3	3
CNS	ST14 →	-0.267	-0.907	<.001	<.001	3	3
CNS	C6 →	-0.282	-0.885	<.001	.001	3	3
URINARY_TRACT	PTGIS →	+0.250	+0.204	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CRIM1 by Regulation of cell-substrate adhesion activity — CNS

Explore this box plot interactively →