Regulation of cell-substrate adhesion

Across TCGA cell cohorts, RNA activity of the Regulation of cell-substrate adhesion pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAX, CYP2W1, and TEAD1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAX grouped by Regulation of cell-substrate adhesion-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MAX →	-0.438	-0.105	<.001	<.001	3	8
CNS	CYP2W1 →	-0.252	-0.083	.005	<.001	3	7
LIVER	TEAD1 →	+0.551	+0.044	.003	.007	1	8
STOMACH	TLN1 →	+0.446	+0.067	.001	.002	2	7
LARGE_INTESTINE	KCNG3 →	+0.211	+0.074	.001	<.001	3	6
BONE	ZNF768 →	-0.335	-0.165	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAX by Regulation of cell-substrate adhesion activity — LUNG_SCLC

Explore this box plot interactively →