Regulation of cell-substrate adhesion

Across TCGA cell cohorts, RNA activity of the Regulation of cell-substrate adhesion pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYH9, AHNAK, and CAPN2, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell-substrate adhesion activity versus MYH9 in BONE (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MYH9 →	+2.105	+0.125	<.001	<.001	3	18
LUNG_NSCLC_LUSC	AHNAK →	+2.783	+0.100	.003	<.001	3	18
LIVER	CAPN2 →	+2.480	+0.073	.005	.006	3	17
BREAST	BMP1 →	+1.698	+0.095	<.001	<.001	3	17
LUNG_NSCLC_LUSC	CCDC9B →	+3.991	+0.109	<.001	<.001	3	17
LIVER	CDC42EP3 →	+3.987	+0.078	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010810 vs MYH9 — BONE

Explore this scatter interactively →