Regulation of cell-substrate adhesion

Across TCGA cell cohorts, RNA activity of the Regulation of cell-substrate adhesion pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C9orf116, RHOC, and TMEM170B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell-substrate adhesion activity versus C9orf116 in SOFT_TISSUE (Pearson r = -0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C9orf116 →	-2.083	-0.204	<.001	.004	3	6
SKIN	RHOC →	+1.266	+0.186	.001	.002	3	5
BONE	TMEM170B →	-1.904	-0.234	.002	.008	3	5
CNS	GALNT5 →	+2.547	+0.179	<.001	.002	2	6
CNS	CCDC80 →	+3.124	+0.229	.004	<.001	3	5
BONE	CD82 →	+2.973	+0.198	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010810 vs C9orf116 — SOFT_TISSUE

Explore this scatter interactively →