Regulation of synaptic vesicle priming

Across TCGA patient cohorts, RNA activity of the Regulation of synaptic vesicle priming pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDR16C5, MCM3, and CACNA1D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synaptic vesicle priming activity versus SDR16C5 in BRCA (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SDR16C5 →	+1.770	+0.706	<.001	.001	3	5
LSCC	MCM3 →	-0.518	-0.621	<.001	<.001	3	5
LUAD	CACNA1D →	+1.002	+0.511	<.001	.001	3	4
BRCA	CYP2B7P →	+2.790	+0.758	.002	<.001	3	4
BRCA	ERBB3 →	+1.071	+0.568	<.001	.002	3	4
LUAD	CACNA2D2 →	+1.836	+0.582	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010807 vs SDR16C5 — BRCA

Explore this scatter interactively →