Negative regulation of peptidyl-threonine phosphorylation

Across TCGA patient cohorts, RNA activity of the Negative regulation of peptidyl-threonine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC9A3R1, PREB, and LEAP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of peptidyl-threonine phosphorylation activity versus SLC9A3R1 in HNSC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLC9A3R1 →	+0.859	+0.319	<.001	.002	3	4
CCRCC	PREB →	+0.257	+0.253	.004	.001	3	3
LUAD	LEAP2 →	+0.478	+0.827	<.001	<.001	3	3
LUAD	C1orf100 →	+0.426	+0.687	<.001	<.001	3	3
PDAC	SNRPGP12 →	+0.581	+0.651	<.001	<.001	3	3
GBM	PCBD1 →	+0.350	+0.236	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010801 vs SLC9A3R1 — HNSC

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