Negative regulation of peptidyl-threonine phosphorylation

Across TCGA cell cohorts, RNA activity of the Negative regulation of peptidyl-threonine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NIBAN2, ZSWIM3, and VDR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NIBAN2 grouped by Negative regulation of peptidyl-threonine phosphorylation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NIBAN2 →	-3.781	-1.707	.002	<.001	3	5
OVARY	ZSWIM3 →	+0.751	+1.547	.001	<.001	3	4
CNS	VDR →	-1.677	-1.501	.001	<.001	3	4
CNS	MRPL17 →	-0.790	-1.122	.006	.003	3	4
CNS	CLMP →	-3.590	-1.496	.002	.006	3	4
CNS	ALKBH2 →	+1.102	+1.390	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NIBAN2 by Negative regulation of peptidyl-threonine phosphorylation activity — CNS

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