Negative regulation of peptidyl-threonine phosphorylation

Across TCGA cell cohorts, RNA activity of the Negative regulation of peptidyl-threonine phosphorylation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMC1A, KCMF1, and FBXL14, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMC1A grouped by Negative regulation of peptidyl-threonine phosphorylation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SMC1A →	+0.519	+1.192	.006	.008	3	2
LUNG_SCLC	KCMF1 →	+0.234	+0.442	.003	.005	3	2
LARGE_INTESTINE	FBXL14 →	+0.185	+0.419	<.001	<.001	3	2
LARGE_INTESTINE	GALR2 →	-0.178	-0.314	.005	.006	3	2
LARGE_INTESTINE	FOXD4L4 →	-0.184	-0.306	.004	.004	3	2
LARGE_INTESTINE	ZNF559 →	+0.374	+0.314	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMC1A by Negative regulation of peptidyl-threonine phosphorylation activity — SKIN

Explore this box plot interactively →