Negative regulation of peptidyl-threonine phosphorylation

Across TCGA cell cohorts, RNA activity of the Negative regulation of peptidyl-threonine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CADM4, PPP2R3A, and FZD4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of peptidyl-threonine phosphorylation activity versus CADM4 in LUNG_NSCLC_LUAD (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CADM4 →	+1.652	+0.324	.003	.006	3	5
CNS	PPP2R3A →	+1.441	+1.202	.002	.007	3	4
LARGE_INTESTINE	FZD4 →	+1.365	+0.411	.001	.009	3	3
LUNG_NSCLC_LUAD	ATP5IF1 →	-0.932	-0.313	<.001	.009	3	3
BREAST	CADPS2 →	+2.512	+0.448	<.001	.003	3	3
LARGE_INTESTINE	SMO →	+2.515	+0.336	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010801 vs CADM4 — LUNG_NSCLC_LUAD

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