Regulation of peptidyl-threonine phosphorylation

Across TCGA patient cohorts, RNA activity of the Regulation of peptidyl-threonine phosphorylation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UCHL1, FKBP9, and FKBP10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of peptidyl-threonine phosphorylation activity versus UCHL1 in LSCC (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UCHL1 →	+0.968	+0.047	.003	.001	3	7
BRCA	FKBP9 →	+0.457	+0.047	<.001	<.001	3	6
LSCC	FKBP10 →	+0.350	+0.030	.009	.009	3	6
BRCA	PLOD1 →	+0.560	+0.037	<.001	<.001	3	6
BRCA	CEP170 →	+0.367	+0.041	<.001	<.001	3	5
OV	SAFB2 →	-0.295	-0.049	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010799 vs UCHL1 — LSCC

Explore this scatter interactively →