Regulation of peptidyl-threonine phosphorylation

Across TCGA cell cohorts, RNA activity of the Regulation of peptidyl-threonine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LSM6, THRAP3, and RGS10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of peptidyl-threonine phosphorylation activity versus LSM6 in LARGE_INTESTINE (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LSM6 →	+0.668	+1.044	.001	.002	3	6
PANCREAS	THRAP3 →	+0.573	+0.982	.001	.006	3	6
CNS	RGS10 →	+1.651	+1.044	.002	.003	3	6
BLOOD_Myeloma	HPF1 →	+1.416	+0.282	<.001	.005	3	5
UPPER_AERODIGESTIVE_TRACT	MRPL19 →	+1.063	+1.469	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	EIF4H →	+0.598	+1.387	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010799 vs LSM6 — LARGE_INTESTINE

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