Regulation of mRNA export from nucleus

Across TCGA patient cohorts, RNA activity of the Regulation of mRNA export from nucleus pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL4, SART3, and GBF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mRNA export from nucleus activity versus RPL4 in LUAD (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL4 →	-0.301	-0.044	<.001	<.001	3	6
LSCC	SART3 →	+0.272	+0.056	<.001	<.001	3	6
COAD	GBF1 →	-0.155	-0.067	.002	.001	3	6
GBM	ARFGAP3 →	-0.347	-0.052	<.001	.001	3	6
HNSC	SMARCC2 →	+0.214	+0.076	<.001	.001	3	6
CCRCC	GLRX3 →	-0.210	-0.029	.003	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010793 vs RPL4 — LUAD

Explore this scatter interactively →