Regulation of mRNA export from nucleus

Across TCGA patient cohorts, RNA activity of the Regulation of mRNA export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPF, KIF11, and ABCA8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mRNA export from nucleus activity versus CENPF in BRCA (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CENPF →	+0.904	+0.616	<.001	<.001	3	5
BRCA	KIF11 →	+0.885	+0.693	<.001	.001	3	5
COAD	ABCA8 →	-0.677	-0.362	.001	.002	3	4
BRCA	SPAG5 →	+0.960	+0.603	<.001	.003	3	4
BRCA	RAD54L →	+0.755	+0.592	.002	.008	3	4
COAD	AURKA →	+0.625	+0.443	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010793 vs CENPF — BRCA

Explore this scatter interactively →