Regulation of mRNA export from nucleus

Across TCGA cell cohorts, RNA activity of the Regulation of mRNA export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTSD, SLFN11, and FNDC4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTSD grouped by Regulation of mRNA export from nucleus-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CTSD →	+1.574	+0.288	.002	<.001	3	4
URINARY_TRACT	SLFN11 →	-2.950	-0.233	.003	.006	3	4
OESOPHAGUS	FNDC4 →	-1.537	-0.252	.001	.001	3	4
OESOPHAGUS	NUDT17 →	-1.363	-0.246	.002	.007	3	4
LUNG_NSCLC_LUAD	BBS12 →	-0.651	-0.949	<.001	<.001	3	3
BONE	LACTB →	+2.164	+1.323	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTSD by Regulation of mRNA export from nucleus activity — LIVER

Explore this box plot interactively →