Positive regulation of cell morphogenesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JRK, DDX17, and CPSF6, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell morphogenesis activity versus JRK in UCS (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	JRK →	+1.009	+0.047	<.001	<.001	3	32
UVM	DDX17 →	+1.273	+0.040	<.001	<.001	3	31
UVM	CPSF6 →	+0.916	+0.035	<.001	<.001	3	31
THYM	USP34 →	+1.386	+0.039	<.001	<.001	3	31
THYM	ASH1L →	+1.313	+0.041	<.001	<.001	3	31
ACC	NRDE2 →	+0.731	+0.032	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010770 vs JRK — UCS

Explore this scatter interactively →