Positive regulation of cell morphogenesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS5, SEPTIN11, and TLN2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell morphogenesis activity versus RPS5 in PDAC (Pearson r = -0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RPS5 →	-0.182	-0.043	<.001	.001	3	6
PDAC	SEPTIN11 →	+0.371	+0.038	<.001	.002	3	6
LSCC	TLN2 →	+0.666	+0.063	<.001	<.001	3	6
LSCC	CALD1 →	+0.552	+0.042	<.001	<.001	3	6
CCRCC	CALD1_S518 →	+0.671	+0.043	<.001	.001	3	6
PDAC	DENND2D →	-0.341	-0.030	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010770 vs RPS5 — PDAC

Explore this scatter interactively →