Positive regulation of cell morphogenesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADA2, ARHGAP18, and CLCN3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell morphogenesis activity versus ADA2 in COAD (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ADA2 →	-0.796	-0.556	.002	.008	3	4
CCRCC	ARHGAP18 →	-0.350	-0.224	<.001	.003	3	4
LUAD	CLCN3 →	+0.331	+0.739	.005	.002	3	4
LSCC	POLR3B →	+0.405	+0.563	<.001	.005	3	3
LSCC	PIK3R5 →	-0.359	-0.438	.005	.008	3	3
HNSC	IFNLR1 →	+0.516	+0.379	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010770 vs ADA2 — COAD

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