Positive regulation of cell morphogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPO, ZNF324, and ARHGAP33, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell morphogenesis activity versus TSPO in BLOOD_Leukemia (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TSPO →	-2.154	-0.178	.005	.002	3	6
SOFT_TISSUE	ZNF324 →	+0.721	+0.178	.004	.007	3	5
SOFT_TISSUE	ARHGAP33 →	+1.529	+0.251	.001	.007	3	5
OVARY	TMCC1 →	+1.021	+0.218	<.001	.002	3	5
BREAST	TNRC6C →	+1.304	+0.218	<.001	.004	3	5
URINARY_TRACT	DTYMK →	-0.857	-0.333	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010770 vs TSPO — BLOOD_Leukemia

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