Negative regulation of fibroblast migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of fibroblast migration pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DFFB, LONP2, and R3HDM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DFFB grouped by Negative regulation of fibroblast migration-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DFFB →	-0.713	-0.975	.007	.003	3	5
BLOOD_Leukemia	LONP2 →	-0.454	-1.078	.007	.001	3	4
BLOOD_Leukemia	R3HDM1 →	-0.728	-0.944	.001	.004	2	5
SOFT_TISSUE	ANAPC1 →	-0.790	-1.252	.004	.004	3	4
BREAST	ANKMY1 →	-0.534	-0.683	.004	.004	3	3
BREAST	ZNF713 →	-0.871	-0.786	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DFFB by Negative regulation of fibroblast migration activity — LARGE_INTESTINE

Explore this box plot interactively →