Negative regulation of fibroblast migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of fibroblast migration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LYSMD1, NKIRAS2, and MSL3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of fibroblast migration activity versus LYSMD1 in BLOOD_Leukemia (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LYSMD1 →	+1.037	+0.160	.001	.006	3	4
SOFT_TISSUE	NKIRAS2 →	-1.022	-0.254	.006	<.001	3	4
BLOOD_Leukemia	MSL3 →	+0.618	+0.170	.001	.001	3	4
KIDNEY	EHD4 →	-1.574	-0.180	<.001	.007	3	4
PANCREAS	TRIM52 →	-0.744	-0.302	.007	.004	3	4
BLOOD_Lymphoma	NAXD →	-0.807	-0.229	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010764 vs LYSMD1 — BLOOD_Leukemia

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