Positive regulation of fibroblast migration

Across TCGA patient cohorts, RNA activity of the Positive regulation of fibroblast migration pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO, CAVIN1, and CAVIN3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fibroblast migration activity versus SYNPO in OV (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SYNPO →	+0.456	+0.083	<.001	<.001	3	10
BRCA	CAVIN1 →	+0.774	+0.061	<.001	<.001	3	10
BRCA	CAVIN3 →	+0.747	+0.061	<.001	<.001	3	10
BRCA	DCN →	+0.947	+0.058	<.001	<.001	3	10
UCEC	OLFML1 →	+1.112	+0.110	<.001	<.001	3	10
COAD	PPM1F →	+0.248	+0.088	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010763 vs SYNPO — OV

Explore this scatter interactively →