Positive regulation of fibroblast migration

Across TCGA cell cohorts, RNA activity of the Positive regulation of fibroblast migration pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD1, SEMA4G, and GULP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANKRD1 grouped by Positive regulation of fibroblast migration-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ANKRD1 →	+3.501	+1.155	.001	<.001	3	5
LIVER	SEMA4G →	-2.826	-1.166	.001	.002	3	4
URINARY_TRACT	GULP1 →	+4.343	+2.039	<.001	<.001	3	4
LUNG_NSCLC_LUAD	PSMB10 →	+0.855	+0.706	<.001	.007	3	4
STOMACH	C4orf3 →	+0.898	+1.267	<.001	<.001	3	4
OESOPHAGUS	MANEAL →	+1.662	+0.907	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANKRD1 by Positive regulation of fibroblast migration activity — OESOPHAGUS

Explore this box plot interactively →