Positive regulation of fibroblast migration

Across TCGA cell cohorts, RNA activity of the Positive regulation of fibroblast migration pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSACC, GAA, and THG1L, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fibroblast migration activity versus TSACC in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TSACC →	-0.690	-0.596	.009	<.001	3	6
CNS	GAA →	-1.534	-0.347	.004	.009	3	5
OESOPHAGUS	THG1L →	-0.744	-0.342	<.001	.006	3	5
LIVER	GSR →	-1.591	-0.505	.004	.002	3	5
LUNG_NSCLC_LUSC	PUS3 →	-0.643	-0.389	.001	.002	3	4
LUNG_NSCLC_LUSC	CHRNG →	-0.082	-0.389	.009	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010763 vs TSACC — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →