Regulation of fibroblast migration

Across TCGA patient cohorts, RNA activity of the Regulation of fibroblast migration pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKAP12, CHRDL1, and C7, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fibroblast migration activity versus AKAP12 in BRCA (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AKAP12 →	+1.156	+0.698	<.001	<.001	3	10
COAD	CHRDL1 →	+1.509	+0.622	<.001	.003	3	7
UCEC	C7 →	+1.849	+0.322	<.001	<.001	3	7
BRCA	RHOJ →	+0.664	+0.412	<.001	<.001	3	7
UCEC	ABCA8 →	+1.442	+0.322	<.001	<.001	3	7
LSCC	ADH1B →	+1.493	+0.335	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010762 vs AKAP12 — BRCA

Explore this scatter interactively →