Regulation of fibroblast migration

Across TCGA cell cohorts, RNA activity of the Regulation of fibroblast migration pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POGZ, SEC24D, and PNN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POGZ grouped by Regulation of fibroblast migration-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	POGZ →	-0.917	-1.029	.006	<.001	3	6
BLOOD_Lymphoma	SEC24D →	+1.134	+1.172	.001	.006	2	5
BLOOD_Leukemia	PNN →	-1.009	-1.043	.007	.003	3	4
BLOOD_Leukemia	NOL9 →	-0.633	-1.246	.004	<.001	3	4
BLOOD_Leukemia	MASP2 →	-0.744	-1.177	.001	.001	3	4
PANCREAS	ZNF219 →	-1.268	-0.924	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POGZ by Regulation of fibroblast migration activity — BREAST

Explore this box plot interactively →