Regulation of fibroblast migration

Across TCGA cell cohorts, RNA activity of the Regulation of fibroblast migration pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC8, GAL3ST4, and MED11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fibroblast migration activity versus DNAJC8 in PANCREAS (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DNAJC8 →	+0.545	+0.202	.002	.003	3	5
BONE	GAL3ST4 →	+1.772	+0.288	.009	.004	2	6
LIVER	MED11 →	-0.894	-0.249	.002	.004	3	4
LIVER	RHEB →	+0.743	+0.321	.008	.002	3	4
LIVER	BCL7C →	+1.024	+0.309	<.001	<.001	3	4
URINARY_TRACT	TCFL5 →	+0.746	+0.322	.003	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010762 vs DNAJC8 — PANCREAS

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