Fibroblast migration

Across TCGA patient cohorts, RNA activity of the Fibroblast migration pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GUCY1B1, MYLK, and PPM1F, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fibroblast migration activity versus GUCY1B1 in UCEC (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GUCY1B1 →	+0.461	+0.061	<.001	<.001	3	10
UCEC	MYLK →	+0.847	+0.080	<.001	<.001	3	10
UCEC	PPM1F →	+0.319	+0.080	<.001	<.001	3	10
HNSC	PRKG1 →	+0.565	+0.084	<.001	<.001	3	10
BRCA	VCL_S795 →	+0.677	+0.045	<.001	<.001	3	10
LSCC	GEM_S23 →	+0.819	+0.057	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010761 vs GUCY1B1 — UCEC

Explore this scatter interactively →