Fibroblast migration

Across TCGA cell cohorts, RNA activity of the Fibroblast migration pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLMAP, KATNAL1, and TBC1D5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLMAP grouped by Fibroblast migration-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SLMAP →	-0.826	-0.871	<.001	.002	3	6
BREAST	KATNAL1 →	-1.246	-0.944	<.001	<.001	3	5
BREAST	TBC1D5 →	-1.060	-1.038	<.001	.001	3	5
BREAST	CCNG1 →	-1.149	-1.014	<.001	.001	3	4
SOFT_TISSUE	UBP1 →	-0.753	-1.013	<.001	<.001	3	4
BREAST	EHD3 →	-0.805	-1.065	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLMAP by Fibroblast migration activity — SOFT_TISSUE

Explore this box plot interactively →