Fibroblast migration

Across TCGA cell cohorts, RNA activity of the Fibroblast migration pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM48, PARP6, and WWTR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRIM48 grouped by Fibroblast migration-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TRIM48 →	+0.266	+0.187	.001	.005	3	4
LIVER	PARP6 →	-0.241	-0.279	.001	<.001	3	4
SOFT_TISSUE	WWTR1 →	+0.187	+0.176	.005	.008	1	6
URINARY_TRACT	NSUN7 →	-0.430	-0.235	<.001	.005	3	4
OVARY	SLC7A10 →	+0.119	+0.129	.007	.002	3	4
OVARY	DYRK1A →	-0.255	-0.206	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRIM48 by Fibroblast migration activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →