Fibroblast migration

Across TCGA cell cohorts, RNA activity of the Fibroblast migration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDLIM1, TGFB1I1, and GBP3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fibroblast migration activity versus PDLIM1 in BLOOD_Leukemia (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PDLIM1 →	+2.988	+0.213	.001	<.001	3	9
OVARY	TGFB1I1 →	+2.794	+0.289	<.001	.001	3	8
STOMACH	GBP3 →	+2.745	+0.419	.004	.001	3	8
BREAST	PML →	+1.232	+0.277	.002	<.001	2	9
LIVER	S100A3 →	+3.359	+0.465	.006	.004	3	7
BREAST	CASP4 →	+3.055	+0.279	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010761 vs PDLIM1 — BLOOD_Leukemia

Explore this scatter interactively →