Fibroblast migration

Across TCGA cell cohorts, RNA activity of the Fibroblast migration pathway is significantly associated with the protein abundance of multiple proteins, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PDLIM1, PML, and ANXA2, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fibroblast migration activity versus PDLIM1 in SOFT_TISSUE (Pearson r = 0.89).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PDLIM1 →	+2.882	+0.624	<.001	<.001	3	18
OVARY	PML →	+2.036	+0.387	<.001	<.001	3	17
BLOOD_Lymphoma	ANXA2 →	+3.094	+0.369	<.001	<.001	3	15
LUNG_SCLC	TMOD3 →	+0.936	+0.384	<.001	<.001	3	12
URINARY_TRACT	IQGAP1 →	+2.059	+0.400	<.001	<.001	3	11
BONE	PLEC →	+2.315	+0.391	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010761 vs PDLIM1 — SOFT_TISSUE

Explore this scatter interactively →