Negative regulation of macrophage chemotaxis

Across TCGA patient cohorts, RNA activity of the Negative regulation of macrophage chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMED10, PGLYRP2, and SYTL3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of macrophage chemotaxis activity versus TMED10 in BRCA (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TMED10 →	+0.839	+0.039	.001	<.001	3	3
LSCC	PGLYRP2 →	+0.129	+0.079	<.001	<.001	3	2
PDAC	SYTL3 →	+0.546	+0.050	.004	.001	3	2
PDAC	AFDN-DT →	-0.221	-0.034	.006	.004	3	2
BRCA	XBP1 →	+1.919	+0.031	.006	.004	3	2
LSCC	LGALSL →	-0.572	-0.069	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010760 vs TMED10 — BRCA

Explore this scatter interactively →