Positive regulation of macrophage chemotaxis

Across TCGA cell cohorts, RNA activity of the Positive regulation of macrophage chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC41A1, PEA15, and NUDC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of macrophage chemotaxis activity versus SLC41A1 in PANCREAS (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SLC41A1 →	+1.120	+1.446	.002	<.001	3	4
PANCREAS	PEA15 →	+0.993	+1.182	<.001	.001	3	4
OVARY	NUDC →	+0.606	+0.930	.002	.007	3	4
LARGE_INTESTINE	ASH2L →	+0.990	+1.165	.002	.004	2	4
LUNG_NSCLC_LUAD	CPOX →	+0.792	+0.932	.002	.002	2	4
SKIN	IFT22 →	+0.702	+0.295	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010759 vs SLC41A1 — PANCREAS

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