Regulation of macrophage chemotaxis

Across TCGA cell cohorts, RNA activity of the Regulation of macrophage chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAP1GDS1, DDT, and ESS2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of macrophage chemotaxis activity versus RAP1GDS1 in OESOPHAGUS (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RAP1GDS1 →	+0.778	+0.281	.009	.002	3	7
LARGE_INTESTINE	DDT →	+0.960	+0.345	.007	.004	3	6
LUNG_NSCLC_LUAD	ESS2 →	+0.772	+0.231	<.001	.001	3	6
LUNG_NSCLC_LUSC	KCTD17 →	+1.777	+0.357	.004	.007	2	6
BLOOD_Leukemia	PPIL2 →	+0.315	+0.127	.009	.004	3	5
URINARY_TRACT	SLC25A12 →	+0.751	+0.502	.005	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010758 vs RAP1GDS1 — OESOPHAGUS

Explore this scatter interactively →