Positive regulation of plasminogen activation

Across TCGA patient cohorts, RNA activity of the Positive regulation of plasminogen activation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLGRKT, LATS2_S576, and RPL7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of plasminogen activation activity versus PLGRKT in LSCC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PLGRKT →	+0.567	+0.060	<.001	<.001	3	5
CCRCC	LATS2_S576 →	+0.182	+0.050	.003	.004	3	5
GBM	RPL7 →	+0.314	+0.060	<.001	<.001	3	4
PDAC	SH3BGRL2 →	-0.440	-0.063	<.001	.002	3	4
PDAC	CAVIN2 →	-0.585	-0.080	<.001	<.001	3	4
GBM	CNTLN_S22 →	+0.562	+0.087	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010756 vs PLGRKT — LSCC

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