Positive regulation of plasminogen activation

Across TCGA cell cohorts, RNA activity of the Positive regulation of plasminogen activation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A10, ANXA2, and ACTN4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of plasminogen activation activity versus S100A10 in LIVER (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	S100A10 →	+2.352	+0.272	.003	.001	3	9
LUNG_SCLC	ANXA2 →	+2.435	+0.228	<.001	<.001	3	9
BLOOD_Myeloma	ACTN4 →	+1.350	+0.332	.005	.005	3	6
LUNG_NSCLC_LUAD	LMNA →	+0.607	+0.137	.004	<.001	3	6
BLOOD_Lymphoma	PXDC1 →	+3.094	+0.259	.001	.006	3	6
BREAST	CRIM1 →	+2.012	+0.133	<.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010756 vs S100A10 — LIVER

Explore this scatter interactively →