Regulation of plasminogen activation

Across TCGA cell cohorts, RNA activity of the Regulation of plasminogen activation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAPN2, HRH1, and LIF, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAPN2 grouped by Regulation of plasminogen activation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CAPN2 →	-1.012	-0.978	<.001	<.001	3	6
CNS	HRH1 →	-1.071	-0.884	.005	.003	3	5
SKIN	LIF →	-1.859	-0.977	.007	.002	3	5
LUNG_NSCLC_LUSC	IL7R →	-4.128	-1.195	.003	.005	3	4
LUNG_NSCLC_LUAD	PLAUR →	-1.596	-0.936	.002	<.001	3	4
CNS	TMEM234 →	-0.517	-0.737	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAPN2 by Regulation of plasminogen activation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →