Regulation of plasminogen activation

Across TCGA cell cohorts, RNA activity of the Regulation of plasminogen activation pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLN1, RAC1, and TFPI, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TLN1 grouped by Regulation of plasminogen activation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TLN1 →	+0.367	+0.333	.003	.004	3	10
BREAST	RAC1 →	+0.242	+0.158	.008	.006	2	8
BONE	TFPI →	-0.429	-0.364	.001	.001	3	6
BREAST	ANKRD13C →	+0.156	+0.157	.001	.004	3	6
BREAST	RPN2 →	+0.534	+0.182	<.001	.006	3	6
BONE	MAX →	-0.698	-0.406	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TLN1 by Regulation of plasminogen activation activity — CNS

Explore this box plot interactively →