Regulation of plasminogen activation

Across TCGA cell cohorts, RNA activity of the Regulation of plasminogen activation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA2, CTSZ, and ACSS2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of plasminogen activation activity versus ANXA2 in LUNG_SCLC (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ANXA2 →	+2.466	+0.256	.003	.002	2	8
OVARY	CTSZ →	+2.520	+0.240	.003	.002	3	6
URINARY_TRACT	ACSS2 →	+0.853	+0.302	.005	.004	3	5
OVARY	CAPG →	+2.870	+0.240	.001	.001	3	5
BREAST	COQ8A →	-1.156	-0.299	.003	.003	3	4
LARGE_INTESTINE	BLZF1 →	+0.771	+0.233	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010755 vs ANXA2 — LUNG_SCLC

Explore this scatter interactively →