Positive regulation of nitric oxide mediated signal transduction

Across TCGA patient cohorts, RNA activity of the Positive regulation of nitric oxide mediated signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GUCY1A1, GUCY1B1, and CYGB, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of nitric oxide mediated signal transduction activity versus GUCY1A1 in UCEC (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GUCY1A1 →	+0.476	+0.080	<.001	<.001	3	9
UCEC	GUCY1B1 →	+0.627	+0.116	<.001	<.001	3	9
OV	CYGB →	+0.590	+0.058	.008	.006	2	9
UCEC	PRKG1 →	+0.897	+0.102	<.001	<.001	3	8
UCEC	RSU1 →	+0.531	+0.090	<.001	<.001	3	8
PDAC	SYNPO →	+0.593	+0.157	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010750 vs GUCY1A1 — UCEC

Explore this scatter interactively →