Positive regulation of nitric oxide mediated signal transduction

Across TCGA cell cohorts, RNA activity of the Positive regulation of nitric oxide mediated signal transduction pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INS, EGFR, and UNKL, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, INS grouped by Positive regulation of nitric oxide mediated signal transduction-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	INS →	-0.377	-1.880	.001	<.001	3	10
STOMACH	EGFR →	-0.503	-1.512	<.001	<.001	3	10
SKIN	UNKL →	-0.284	-1.446	<.001	<.001	3	8
OVARY	ASNSD1 →	-0.336	-1.089	<.001	<.001	3	6
BLOOD_Leukemia	PZP →	-0.226	-1.485	<.001	<.001	3	6
LARGE_INTESTINE	CRIM1 →	-0.230	-1.236	.002	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

INS by Positive regulation of nitric oxide mediated signal transduction activity — SOFT_TISSUE

Explore this box plot interactively →