Positive regulation of nitric oxide mediated signal transduction

Across TCGA cell cohorts, RNA activity of the Positive regulation of nitric oxide mediated signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAP1, TOR2A, and ZNF226, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAP1 grouped by Positive regulation of nitric oxide mediated signal transduction-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CAP1 →	-0.905	-1.167	<.001	<.001	3	4
LUNG_SCLC	TOR2A →	+0.911	+0.987	<.001	.004	3	4
LARGE_INTESTINE	ZNF226 →	+1.476	+1.296	.003	.004	3	4
LARGE_INTESTINE	CD44 →	-1.948	-1.277	.004	.003	3	4
BLOOD_Leukemia	FHL3 →	-1.304	-0.533	.003	.008	3	4
LUNG_NSCLC_LUSC	DKK3 →	-3.597	-1.164	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAP1 by Positive regulation of nitric oxide mediated signal transduction activity — BREAST

Explore this box plot interactively →