Regulation of nitric oxide mediated signal transduction

Across TCGA patient cohorts, RNA activity of the Regulation of nitric oxide mediated signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EGFR, ZFP36, and RHOJ, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nitric oxide mediated signal transduction activity versus EGFR in GBM (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EGFR →	+2.757	+0.597	<.001	<.001	3	4
OV	ZFP36 →	+1.072	+0.600	<.001	<.001	3	3
CCRCC	RHOJ →	+0.605	+0.588	.003	.009	3	3
CCRCC	PRKD1 →	+0.474	+0.729	.004	.002	3	3
CCRCC	C11orf96 →	+0.874	+0.629	.002	.003	3	3
CCRCC	PDCL3P6 →	+0.406	+0.818	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010749 vs EGFR — GBM

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