Regulation of nitric oxide mediated signal transduction

Across TCGA cell cohorts, RNA activity of the Regulation of nitric oxide mediated signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DYRK3, GPR176, and CAP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DYRK3 grouped by Regulation of nitric oxide mediated signal transduction-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DYRK3 →	-1.451	-0.875	.007	.003	3	5
STOMACH	GPR176 →	-2.505	-1.080	.003	.004	3	5
LIVER	CAP2 →	-1.244	-1.565	.005	<.001	3	4
CNS	FLI1 →	-1.577	-0.897	<.001	<.001	3	4
KIDNEY	RSU1 →	-1.045	-1.296	.001	<.001	3	4
LIVER	KIAA1549L →	-2.386	-1.696	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DYRK3 by Regulation of nitric oxide mediated signal transduction activity — BLOOD_Leukemia

Explore this box plot interactively →